Capture the pathway
Describe the care delivered
Record presentation, diagnostics, microbiology, antimicrobial therapy, source control, and organ support from routine care.
International time-bound prospective cohort
One emergency.
Many pathways.
A clearer evidence base.
SnapNSTI is a multicentre, non-randomized observational cohort describing how severe skin and soft-tissue infections are recognized, treated, and followed in routine acute care.
Adults ≥18 years · consecutive local window · admission-relative data
6months
Consecutive local
enrolment window
InternationalCollaborative cohort across participating services.
ProspectiveRoutine clinical data captured in real time.
Admission-relativeKey events aligned to a common time zero.
StandardizedShared definitions, quality checks, and governance.
A shared view of urgent infection care
Each centre reconstructs the pathway from routine records so that practice variation can be described clearly and future questions can be designed responsibly.
Compare decision points
Make variation visible
Align decision and treatment timing to admission so services can understand where pathways differ.
Follow meaningful outcomes
Support better questions
Summarize mortality, organ failure-free days, complications, reintervention, and recovery at 90 days.
Current study description: SnapNSTI prospective cohort. The current protocol is version 1.1 dated 8 December 2025. Each centre determines its own audit, ethics, privacy, and data-governance requirements before case inclusion. View the current materials.
The local workflow
From eligible case to shared learning
- 1
Identify
Screen consecutive adult admissions with severe skin and soft-tissue infection during the local window.
- 2
Characterize
Document presentation, diagnostic pathway, microbiology, timing, source control, and support.
- 3
Follow
Complete in-hospital data and the 90-day outcome record, with optional PROMs where locally approved.
- 4
Learn
Use aggregate findings to understand practice variation and design future studies responsibly.
Bring your centre into the collaboration
Join a network studying the real-world pathways, resources, and outcomes that shape care for necrotizing soft-tissue infection.
For centres
Ready to participate?
Start with centre interest, local classification, and a plan for consecutive case ascertainment and 90-day follow-up.
See the participation pathway →For collaborators
Methods, microbiology, and implementation
Review the study description and contact the team about analytic, clinical, or implementation collaboration.
Explore collaborator routes →